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A reliable HBV model is more than a way to reproduce viral persistence selected features of HBV biology in an animal. Its real value depends on whether

Chronic HBV infection involves viral persistence, and host responses and may lead to progressive liver diseasemaking experimental model selection more nuanced than simply reproducing viral presence.

Hepatitis B research requires more than a biologically relevant experimental system; it also demands careful attention to containment, animal welfare, sample handling, and data integrity.