Applicable regulatory requirements and scientific quality standards in preclinical metabolic research extend beyond animal welfare documentation; they also concern scientific justification, experimental consistency, endpoint selection, and
Metabolic disorders develop through interconnected changes in energy balance, glucose regulation, lipid handling, inflammation, and organ function, so model selection cannot rest on a single
Metabolic disorders rarely arise from a single biological abnormality. Obesity, type 2 diabetes, steatohepatitis, and liver fibrosis involve interconnected changes in energy balance, glucose regulation,
