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Autoimmune disorders arise when immune tolerance to self-antigens is disrupted, leading to immune responses against the body’s own cells or tissues.. The resulting pathology can

Inflammatory disorders can arise from very different immune mechanisms, so a single experimental system rarely answers every research question. Inflammation models in mice are valuable because

Immune dysfunction is rarely driven by a single pathway. Autoimmune disease models allow researchers to examine how immune activation, tissue injury, inflammatory signaling, and disease progression